PKRRATING - AN OVERVIEW

The activated enzyme then phosphorylates its big substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to a conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to diverse stimuli12, triggering the built-in stre